Diabetes mellitus (DM) is a metabolic disease that can affect the central nervous system and behavioral traits in animals.\nStreptozotocin-induced diabetes is considered an autoimmune disease. The aim of the current study was to determine whether\nsupplementation with the alcoholic extract of Avicennia marina leaves could improve diabetes-associated pathological changes.\nThe animals were divided into four groups: a control group (A), an A. marina receiving nondiabetic group (B), a diabetic group\n(C), andaDMgrouporally supplementedwithA.marina alcoholic leaf extract (D).TheDMgroup of animals receiving the alcoholic\nextract of A.marina leaves had reduced blood glucose levels, improved blood picture, and organ functions. This group also showed\nimprovement in locomotory behavior.The results of this study showed that supplementation with the alcoholic extract of A.marina\nleaves reduced oxidative stress and blood sugar levels, protected the liver, and improved the neurobehavioral changes associated\nwith diabetes in mice. Introducing alcoholic leaf extract of A. marina to diabetic mice decreased inflammatory cells aggregation,\nvacuolation, and hemorrhage. Additionally, a positive effect of the alcoholic leaf extract on the histopathological changes was\nobserved in the testicular tissue of treated mice.
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